Colony stimulating factors csfs are secreted glycoproteins that bind to receptor proteins on the surfaces of hemopoietic stem cells, thereby activating intracellular signaling pathways that can cause the cells to proliferate and differentiate into a specific kind of blood cell usually white blood cells. Gcsfs can be used to treat or prevent infections for patients with a low white cell count. Member has risk factors for poor outcomes resulting from febrile neutropenia for example. Choose from 127 different sets of colony stimulating factors flashcards on quizlet. Zarxio is the preferred granulocyte colony stimulating factor gcsf. Is prescribed the colony stimulating factor by or in consultation with a hematologist or oncologist. The patient has a contraindication or severe intolerance to granix and zarxio. Granulocytemacrophage colonystimulating factor wikipedia. The csf family includes csf1 or macrophage csf mcsf, csf2 or granulocyte macrophage csf gmcsf, and csf3 or granulocyte csf gcsf. Direct proliferative actions of stem cell factor on murine bone marrow cells in vitro. It can lead to febrile neutropenia fn, which often requires patients to be hospitalised for intravenous antibiotic therapy. Widely produced in the body, these regulators probably play an important role in resistance to infections. And patient has one or more of the following risk factors for developing infectionrelated complications.
The four colony stimulating factors csfs regulate the generation and some functions of granulocytes and macrophages, and recombinant granulocytecsf and granulocytemacrophagecsf are used to. Granulocyte colony stimulating factor gcsf gcsf is a type of growth factor. Appendix 1 covered diagnosis codes icd10 icd10 description. Granulocyte colony stimulating factor gcsf, or colony stimulating factor 3, is a glycoprotein cytokine that stimulates formation of granulocyte colonies from the proliferation of a single hematopoietic stem cell. Whereas the role played by cytokines as neuronal mediators is no longer contested, the mechanisms by which cytokines modulate pain processing remain to be elucidated. We have compared the in vitro properties of mono cytesmacrophages treated with macrophagecolony stimulating factor mcsf or csf1 and granulocyte. What is the role of colonystimulating factor therapy in the. The granulocytemacrophage colony stimulating factors are wellcharacterized specific glycoproteins that interact to control the production, differentiation, and function of two related white cell populations of the blood, the granulocytes and monocytemacrophages. For primary prophylaxis of chemotherapyinduced febrile neutropenia in patients with nonmyeloid malignancies, one of the following. Dosageadministration indication dose acute radiation exposure 6 mg subcutaneously weekly for 2 doses use weight based dosing below for pediatrics weight colony stimulating factors act on hematopoietic cells and stimulate proliferation, differentiation commitment, and some endcell functional activation. Granulocytemacrophage colony stimulating factor as an.
Granulocyte colony stimulating factor gcsf is a blood growth factor special proteins produced by the body that stimulates the bone marrow to produce more infectionfighting white blood cells called neutrophils. A long acting colony stimulating factor was not received as prophylaxis, and those who previously received zarxio, nivestym, neupogen, or granix will continue with same agent o prophylactic therapy with a colony stimulating factor was not received, and risk factors for poor outcome resulting from febrile neutropenia are present for. Request pdf colony stimulating factors in myelodysplastic syndromes the potential for recombinant growth factors to augment hematopoiesis has been extensively investigated with a. For the coverage criteria below, in absence of specified drug products, the term colony stimulating factors or csfs will be used in this policy where the coverage criteria apply to all products listed above.
The macrophage colony stimulating factor, colony stimulating factor 1 csf1, selectively stimulates the survival, proliferation, and differentiation of mononuclear phagocytes from the determined, undifferentiated progenitor cell, through the various intermediate stages of differentiation monoblast promonocyte monocyte, to the mature macrophage stanley et. Colony stimulating factors csfs, also called haematopoietic growth factors, regulate bone marrow production of circulating red and white cells, and platelets. We assessed the efficacy and safety of granulocyte colony. Individual has not received prophylactic therapy with granulocyte colony stimulating factor nccn guidelines myeloid growth factors. The csf family includes csf1 or macrophage csf mcsf, csf2 or granulocyte macrophage csf gmcsf, and csf3 or. Use of colonystimulating factors with chemotherapy. Colony stimulating factors pa summary preferred nonpreferred granix tbo filgrastim leukine sargramostim neupogen filgrastim fulphila pegfilgrastimjmdb neulasta pegfilgrastim nivestym filgrastimaafi zarxio filgrastimsndz length of authorization. Colonystimulating factors in inflammation and autoimmunity. Colonystimulating factors the myeloid growth factors, and most notably granulocyte colonystimulating factor gcsf, have demonstrated the ability to reduce the incidence and severity of neutropenia and febrile neutropenia while improving chemotherapy dose intensity. Colony stimulating factors in myelodysplastic syndromes. Individual has a high risk for infectionassociated complications as demonstrated by. Colony stimulating factors and myeloid cell biology in.
Granulocyte macrophage colony stimulating factor gmcsf is an antineutropenic, hematopoietic growth factor, which supports survival, clonal expansion, and differentiation of hematopoietic progenitor cells. Hematopoietic colonystimulating factors are a diverse group of cytokines now commercially available through recombinant technology. You might have gcsf after chemotherapy to help your white blood cells recover after treatment. However, the role of csf1r signaling in microglial homeostasis in the adult brain is largely unknown. Neutropenia is a severe drop in infectionfighting white blood cells neutrophils. Dosageadministration indication dose acute radiation exposure 6 mg subcutaneously weekly for 2 doses use weight based dosing below for pediatrics weight colony stimulating factors. Colonystimulating factors an overview sciencedirect topics. White blood cell colony stimulating factors are medically necessary when all of the following criteria are met. Pdf on jan 1, 2016, reza yari and others published granulocyte colonystimulating factor find, read and cite all the research you need on researchgate. Granulocyte colony stimulating factor gcsf and granulocytemacrophage colony stimulating factor gmcsf are glycosylated polypeptides that induce an increase in the proliferation and maturation of white blood cells including neutrophils and monocytesmacrophages. Colonystimulating factors csf are intriguing molecules, which are glycoproteins that control the production and even.
Colony stimulating factor csfmyeloid growth factor mgf clinical guideline. Colony stimulating factors were originally detected and assayed by culturing a source of hematopoietic progenitor cells, such as a cell suspension derived from the bone marrow, in medium that has been jellified by the addition of a substance such as agar or methyl cellulose. The interaction between the immune system and the nervous system has been at the center of multiple research studies in recent years. The importance of the granulocytecolony stimulating. Granulocyte colony stimulating factors linkedin slideshare. Effects of combination with colonystimulating factors. Both infectious diseases society of america idsa and national. Zarxio is the preferred shortacting granulocyte colony stimulating factor product.
Colony stimulating factors csfs prior approval criteria. Administration of exogenous colony stimulating factors stimulates the stem cells in the bone marrow to produce more of the particular white blood cells. November 20, 2019 page 2 of 6 neupogen may be considered medically necessary if. Granulocyte colony stimulating factor gcsf and its related granulocyte macrophage colony stimulating factor gmcsf are glycoproteins belonging to the family of colony stimulating factors csf.
Colony stimulating factors were originally detected and assayed by culturing a. Colonystimulating factor an overview sciencedirect topics. Guideline aapro ms, bohlius j, cameron da, dal lago l, donnelly jp, kearney n, et al. When conditions are met, we will authorize the coverage of colony stimulating factor. Jun 28, 2019 colony stimulating factors csf are intriguing molecules, which are glycoproteins that control the production and even some functions of granulocytes and macrophages, the immune cells that are. Takahashi and associates 1991 have examined the effects of colony stimulating factors on murine osteoclast formation in vitro in a coculture system, and have shown that all these factors can stimulate the growth of osteoclast precursors but, when added simultaneously with l,25oh 2 d 3, inhibit its effects on osteoclast formation. The colonystimulating factors have proven utility in a wide spectrum of cytopenic states, and their use is now commonplace. The colonystimulating factor 1 receptor csf1r is a key regulator of myeloid lineage cells. The importance of the granulocytecolony stimulating factor. Definition of granulocyte colonystimulating factor nci. Or the dose required necessitates use of a vial and cannot be met with the fixeddose 300 mcg. These dna clones have proved valuable for studying the molecular biology of these.
The complementary dnas and genes encoding the four major human myeloid growth factors granulocyte colony stimulating factor, macrophage colony stimulating factor, granulocytemacrophage colony stimulating factor, and interleukin3have all been molecularly cloned. A membersrisk for developing neutropenic fever may be assessed prior to the use of colony stimulating factors. Pdf the development of the therapeutic roles of filgrastim and sargramostim. Not receive colony stimulating factor csfs prophylaxis. Learn vocabulary, terms, and more with flashcards, games, and other study tools. You may contact paramount by phone at 14198872520 with questions regarding the prior authorization process. Colony stimulating factors csf are hematopoietic growth factors, which act on progenitor cells capable of forming either single differentiated lineagespecific cell types, such as the neutrophilic granulocyte, or forming several differentiated cell types i. Or the dose required necessitates use of a vial and cannot be met with the fixeddose 300 mcg or 480 mcg prefilled syringes.
Expected prolonged greater than 10 days and profound less than 0. The granulocytemacrophage colonystimulating factors science. Feb 01, 2018 colony stimulating factors clinical guideline. Granulocyte colony stimulating factor gcsf and granulocytemacrophage colony stimulating factor gmcsf have been used successfully to enhance neutrophil recovery in patients with various malignancies undergoing standard or high dose chemotherapy, with or without autologous or allogeneic bone marrow transplantation support, and offer potential. Requests for non preferred agents require trial of zarxio in addition to meeting the clinical criteria detailed below. The granulocytemacrophage colonystimulating factors.
Colony stimulating factors pa summary preferred nonpreferred granix tbo filgrastim leukine sargramostim neupogen filgrastim fulphila pegfilgrastimjmdb neulasta pegfilgrastim nivestym filgrastimaafi zarxio filgrastimsndz. Colony stimulating factor csf is the operational term for a class of molecules that stimulate hematopoietic progenitor cells to divide and generate colonies of differentiated progeny such as neutrophils or macrophages. Clinical guidelines summary chemotherapyinduced neutropenia cin is a common and serious toxicity of cancer chemotherapy. Colony stimulating factors act on hematopoietic cells and stimulate proliferation, differentiation commitment, and some endcell functional activation. Hgfs involved in regulating the formation of nonlymphoid blood cells. Pdf clinical applications of colonystimulating factors. Colony stimulating factors are glycoproteins that promote production of white blood cells mainly granulocytes such as neutrophils, in response to infection. Nov 15, 2015 granulocyte colony stimulating factor gcsf and its related granulocyte macrophage colony stimulating factor gmcsf are glycoproteins belonging to the family of colony stimulating factors csf. Or you might have it before and after a stem cell transplant.
Colony stimulating factors and macrophage heterogeneity. Recombinant forms of these colony stimulating factors are used to treat severe neutropenia in patients receiving cancer. The colony stimulating factors csfs, granulocyte macrophagecsf gmcsf, macrophagecsf mcsf or csf1 and granulocytecsf gcsf were first. The information in this policy is used by wellmark to make determinations whether medical treatment is covered under the terms of a wellmark members health benefit plan. Clinical practice guidelines for the use of colony. Management of chemotherapyinduced neutropenia with colony. Colony stimulating factors livertox ncbi bookshelf. Myeloid colony stimulating factors csfs decrease the risk of febrile neutropenia fn from highrisk chemotherapy regimens administered to patients at 20% or greater risk of fn, but little is known about their use in clinical practice.
Request pdf colony stimulating factors in myelodysplastic syndromes the potential for recombinant growth factors to augment hematopoiesis has been extensively investigated with a wide range of. This may beachieved byevaluating the degree ofmyelosuppression ofthe members chemotherapy regimen inaddition to the presence ofother memberrelated risk factors. Colonystimulating factors definition of colonystimulating. The colonystimulating factors csfs are hematopoietic growth factors. Therapeutic class overview colony stimulating factors. Pdf the four colony stimulating factors csfs, macrophagecsf mcsf or csf1, granulocytecsf gcsf. Myeloid growth factors specifically, granulocyte colony stimulating factors gcsfs and granulocytemacrophage colony stimulating factor gmcsfsmay shorten the duration of neutropenia in. Schrader, in encyclopedia of immunology second edition, 1998. Granulocyte colony stimulating factor gcsf or gcsf, also known as colony stimulating factor 3 csf 3, is a glycoprotein that stimulates the bone marrow to produce granulocytes and stem cells and release them into the bloodstream functionally, it is a cytokine and hormone, a type of colony stimulating factor, and is produced by a number of different tissues. Renewal criteria same as initial prior authorization policy criteria. In this study, we have analyzed the involvement of granulocytemacrophage colony stimulating. Colony stimulating factors csfs prior approval criteria august 2017 overview colony stimulating factors csfs are biosynthetic products that stimulate the development of white blood cells such as neutrophils and macrophages infectionfighting blood cells. Patients must have failed, or have a contraindication, or intolerance to zarxio prior to consideration of any other shortacting gcsf product. Genetic loss of the csf1r blocks the normal population of resident microglia in the brain that originates from the yolk sac during early development.
Please fax signed forms to paramount at 18442562025. Learn colony stimulating factors with free interactive flashcards. Does not have a history of a contraindication to the prescribed colony stimulating factor. Granulocyte colonystimulating factor gcsf is the primary growth factor responsible for the proliferation and differentiation of bone marrow granulocyte progenitors into mature granulocytes. Food and drug administration fda expanded approval of leukine sargramostim for autologous peripheral blood 011927 091925 271923 331925. Granulocyte colony stimulating factor causes cells from the bone marrow to become mature and activated.
1355 504 1098 201 46 1243 212 1178 654 267 717 1445 380 476 1293 1244 559 201 481 625 1000 1421 906 1212 904 240 1173 771 1557 216 164 1174 669 1369 1188 1383 1379 1336 1357 880 1219 531 703 73 334